Sometimes we go upwards in this universe and sometimes downwards in this universe, which is all based on our karma! In that way everything appears to be predestined! But there is one way that one can break out of this predestined situation, and that is by taking up service to the Supreme Lord, because if one does so then one immediately gets the choice. One immediately becomes free from this destiny. Krishna says in the Bhagavad Gita:
mam ekam saranam vraja
aham tvam sarva-paprebhyo
moksayisyami ma suca (BG 18.66)
‘Don’t fear I will liberate you from all this ‘pāpebhyo’ from all these sinful reactions’.
So if we do all the surrendering to Krishna, then He will remove the sinful reactions!